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Improve Prostate Biopsy Accuracy and Cancer Detection Rates with 3D MRI/Ultrasound Fusion

MRI/ultrasound fusion technology can be the most accurate and efficient way to biopsy suspicious areas of the prostate. It helps urologists minimize overtreatment of non-aggressive cancers, reduce unnecessary biopsies, while enhancing your ability to detect aggressive tumors. KOELIS Trinity® offers real-time 3D MRI/ultrasound fusion to help improve cancer detection rates and prostate biopsy accuracy.

Transrectal Probe
fusion biopsy system

Our fusion biopsy system employs advanced Organ-Based Tracking Fusion® (OBT) technology that tracks the prostate, not the probe. OBT automatically compensates for patient and prostate movement with no need to manually realign imagery. The result is exceptionally accurate fusion biopsy as precise as 2.5 mm.1

Achieve Maximum Accuracy with Elastic Fusion vs. Rigid Fusion

KOELIS Trinity® is the most advanced MRI/ultrasound fusion system for targeted prostate biopsy – dynamically tracking prostate and patient movement using patented, Organ-Based Tracking Fusion® (OBT Fusion®). Competitive and conventional MRI/ultrasound fusion systems only use rigid fusion technologies that may display the MRI target in a different location than it actually is, giving the urologist a false sense of sampling the suspect area.

KOELIS Trinity® technology provides significant advantages:

KOELIS Patented Organ-Based Tracking:

  • AI technology automatically compensates for prostate and patient movement.
  • There’s no need for tracking sensors, or for users to manually realign MRI or ultrasound images.
  • With each biopsy needle pass, an updated 3D ultrasound is obtained to improve accuracy.
  • Exceptionally accurate fusion biopsy, as precise as 2.3 mm.1

Competitive Electromagnetic or Robotic Probe Tracking:

  • Tracks the ultrasound probe not the prostate, requiring electromagnetic or mechanical sensors.
  • Does not account for changes in prostate shape, leading to incorrect image registration and needle targeting.
  • Requires constant manual re-alignment of ultrasound and MRI images throughout the procedure.

Understanding the Drawbacks of Existing Diagnostic Methods

Conventional 2D ultrasound biopsy sampling for prostate cancer detection is also known as random sampling, and this diagnostic method has inherent limitations including:

  • The biopsy potentially misses the cancer.
  • The biopsy undersamples a clinically significant tumor, thus underestimating the patient's actual risk group and preventing a reliable treatment strategy.
  • The biopsy oversamples a non-clinically significant tumor, which may lead to overestimating the cancer stage and overtreating the patient out of caution.

KOELIS Trinity®’s Fully Integrated Ultrasound Supports Multiple Urologic Procedures

Our versatile system can also be used to support targeted focal therapies such as:

High-intensity focused ultrasound (HIFU)


Hydrogel Rectal Spacer

Fiducial Marker Placement

You can further increase system ROI by adding specialty ultrasound probes that support other urology-related procedures. Additional abdominal and small parts probes can be used for ongoing routine scans in the office or surgery center including testicular scans, kidney scans and bladder scans.


1. Mean precision was 2.3 mm (95% confidence interval: 1.8 mm, 3.3 mm). Positive cores were closer to the center than were negative cores (dCC: 1.7 mm vs 3.1 mm, respectively; P = .025) https://pubmed.ncbi.nlm.nih.gov/29361246/ Precision Matters in MR Imaging-targeted Prostate Biopsies: Evidence from a Prospective Study of Cognitive and Elastic Fusion Registration Transrectal Biopsies François Cornud , Mathieu Roumiguié, Nicolas Barry de Longchamps , Guillaume Ploussard , Eric Bruguière , Daniel Portalez, Bernard Malavaud


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